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Antigenic Specificity | HLA-DR/DP/DQ |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 100 µl |
Concentration | 1000 µg/ml |
Applications | WB, IHC, ICC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]. In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ?70% similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival. |
Immunogen | Cells from human tonsil |
Other Names | MHC class II antigen DRA; HLA-DRA1; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain |
Gene, Accession # | Gene ID: 3122, Accession: NP_061984.2, UniProt: P01903 |
Catalog # | A500-034ACF |
Price | $691 |
Order / More Info | HLA-DR/DP/DQ Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |