Edit |   |
---|---|
Antigenic Specificity | Spi-6, Mouse |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | unconjugated |
Size | 100 µg |
Concentration | n/a |
Applications | Flow cytometry, Immuno assays, Western blot. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6. |
Immunogen | Recombinant GST-Spi-6 |
Other Names | Cytoplasmic antiproteinase 3, serpin B9, PI-9 |
Gene, Accession # | n/a |
Catalog # | HP8035-100UG |
Price | $538 |
Order / More Info | Spi-6, Mouse Antibody from HYCULT BIOTECH |
Product Specific References | n/a |