FHR-4, Human Antibody from HYCULT BIOTECH
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| Antigenic Specificity | FHR-4, Human |
| Clone | 4A.8 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Western blot. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-FHR-2; clone 2.12 is a mouse monoclonal antibody recognizing human full length Complement Factor H-related protein 2 (FHR-2), a glycoprotein belonging to the family of complement regulatory proteins. FHR-2 has a molecular weight of approximately 29 kDa and is synthesized and secreted primarily by the liver but also by various immune cells, including monocytes, macrophages, and dendritic cells. Structurally, FHR-2 shares homology with Complement Factor H (CFH), which is a key regulatory protein within the complement system. Also FHR-2 is involved in the regulation of the complement cascade but its biological role is poorly understood somewhat controversial. Studies showed that FHR-2 inhibits the activity of the complement alternative pathway (AP) C3 convertase, thereby preventing MAC formation. On the other hand, it is described that a hybrid mutant protein consisting of FHR-5 domains and full length FHR-2 causes complement overactivation, which suggests that FHR-2 rather promotes AP activation. Dysregulation of FHR-2 is associated with diseases such as atypical hemolytic uremic syndrome (aHUS) and age-related macular degeneration (AMD). In these diseases, abnormal complement activation and deposition on host tissues can contribute to pathological processes. FHR-2's involvement in the alternative pathway of the complement system positions it as a potential target for therapeutic interventions aimed at modulating complement-related diseases |
| Immunogen | Human Complement factor H-related protein 4 |
| Other Names | CFHL4, CFHR4 |
| Gene, Accession # | n/a |
| Catalog # | HM2438-100UG |
| Price | $488 |
| Order / More Info | FHR-4, Human Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
Profile of HYCULT BIOTECH