Siglec-H, Mouse Antibody from HYCULT BIOTECH
Search, find, compare suppliers for anti-Siglec-H, Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Siglec-H, Mouse |
| Clone | 440c |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | n/a |
| Applications | Flow cytometry, Frozen sections, Functional studies, Paraffin sections. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen. Incubation of IPC with antibody 440c in vitro or administration of antibody 440c in vivo reduces secretion of IFN-alpha in response to CpG DNA without causing IPC depletion. |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | HM1075-20UG |
| Price | $157 |
| Order / More Info | Siglec-H, Mouse Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
Profile of HYCULT BIOTECH