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Antigenic Specificity | IL-13R-alpha-1, Mouse |
Clone | 1G3 |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 20 µg |
Concentration | n/a |
Applications | Flow cytometry, Immuno precipitation, Western blot. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse monoclonal antibody clone 1G3 recognizes mouse Il-13Ralpha1. Il-13 is a cytokine secreted by activated TH2 cells and is important mediator of allergic inflammation. Il-13 signals via interaction with a heterodimeric receptor of Il-4Rα and IL-13Rα. The IL13Rα consist of two cognate receptors, Il13-Rα1 and Il-13Rα2, which are expressed on a wide variety of cells among others B-cells, basophils, eosinophils, and macrophages. IL-13Rα1 is a glycosylated protein of ca 710KD. The receptor itself has a low affinity for IL13. However when paired with Il-4 it has a strong affinity for IL-13. After cytokine binding the receptor signals via JAK/STAT pathway. The heterodimeric receptor signal both with Il-13 and Il-4. Both cytokines have consequently quite comparable function. Il-13Rα2 and the recently discovered soluble Il-13Rα1 are thought to be decoy receptors for Il-13. Il-13 have been associated with diseases like asthma and idiopathic pulmonary fibrosis. Several studies have indeed shown the regulating role of Il-13 in airway hyper-reactivity leading to e.g. mucus secretion, chemokine production and IgE production. There are also indications that IL-13Rα1 is involved in macrophages differentiation and might serve as a biomarker for the M2 population. |
Immunogen | Extracellular mouse IL-13Rα1 |
Other Names | Interleukin-13 receptor subunit alpha-1, IL-13 receptor subunit alpha-1, IL-13R subunit alpha-1, IL-13R-alpha-1, IL-13RA1, Cancer/testis antigen 19, CT19, CD213a1 Gene name: IL13RA1, IL13R, IL13RA Entrez Gene ID 3597 Uniprot P78552 |
Gene, Accession # | n/a |
Catalog # | HM1140-20UG |
Price | $157 |
Order / More Info | IL-13R-alpha-1, Mouse Antibody from HYCULT BIOTECH |
Product Specific References | n/a |