Melanoma associated antigen, Human Antibody from HYCULT BIOTECH

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Antigenic SpecificityMelanoma associated antigen, Human
CloneNKI/beteb
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2b
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsFrozen sections, Immuno fluorescence, Immuno precipitation, Paraffin sections. RUO
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DescriptionMelanoma associated antigen (MAA) is dispersed in the cytoplasma of melanoma cells, and is more concentrated inside vacuoles and sometimes on the melanosomes. Occasionally the antigen is seen on the cell surface. The antigen is actively shed from living cells. Although the antigen is associated with melanomas, it is not codistributed with the tyrosinase activity associated with melagonesis. The antigen shows codistribution with cathepsin D, which is a marker for lysosomal functions. The antibody NKI/beteb recognizes a (pre)melanosomal 100 kD and 7 kD antigen (glycoprotein). The antibody reacts with melanomas, clear cells sarcomas (melanoma of soft tissue), nevocellular nevi, and normal melanocytes. Except for one case of non-Hodgkin's lymphoma in which macrophages were positive, no reactions with other tumors or tissues have been observed.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM2130-100UG
Price$538
Order / More InfoMelanoma associated antigen, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
HYCULT BIOTECH
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353

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