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Antigenic Specificity | S100A7, Human |
Clone | 2D9 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 100 µg |
Concentration | n/a |
Applications | Frozen sections, Functional studies, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Antibody 2D9 recognizes human S100A7 (Psoriasin). S100A7 is a 11.4kDa member of the S100 gene family, which are EF-hand Ca 2+-binding proteins. They are involved in a broad range of intra- and extracellular processes like regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, immune responses, antimicrobial activity, chemotaxis and inflammation. S100 proteins have a fundamental structural unit which is a highly integrated dimer, some as homodimer and others as heterodimer. S100A7 functions as a homodimer and binds two Zn2+ ions. These ions stabilize the dimer and mediate the function of S100A7 during infection. Extracellular S100A7 functions as a DAMP during infection. S100A7 limits bacterial infection through metal limitation. Furthermore, S100A7interacts with RAGE which drives an NF-?B mediated proinflammatory response and recruitment of neutrophils. S100A7 was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Possibly, S100A7 adheres directly to and reduces survival of pathogens found on the epidermis and acts as a physical barrier. S100A7 also seems to be involved with breast cancer and squamous cell carcinoma. In vitro it was found to confer a more aggressive behavior |
Immunogen | Full length human recombinant protein isolated from E.coli. |
Other Names | Protein S100-A7, Psoriasin, S100 calcium-binding protein A7 Gene name: S100A7, PSOR1, S100A7C |
Gene, Accession # | n/a |
Catalog # | HM2329-100UG |
Price | $488 |
Order / More Info | S100A7, Human Antibody from HYCULT BIOTECH |
Product Specific References | n/a |