Transgelin, Human Antibody from HYCULT BIOTECH
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| Antigenic Specificity | Transgelin, Human |
| Clone | 4G4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 20 µg |
| Concentration | n/a |
| Applications | Immuno assays, Paraffin sections, Western blot. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Monoclonal antibody HM2405 clone 4G4 recognizes human transgelin, also called SM-22. Transgelin is a 22 kDa calponin-like protein and exists as different isoforms a-d based on different pH. It is a water-soluble protein which is abundantly expressed by intestinal smooth muscle tissues. Its role is not complete clear but it seems to play a role in differentiation and maturation of smooth muscle cells. Transgelin is considered to be a biomarker for acute intestinal ischemia (AII) and leiomyosarcoma. AII is a relative rare abdominal emergency associated with considerable high morbidity and mortality as a consequence of obstruction of mesenteric blood flow associated with surgical procedures, hemorrhagic shock, trauma and sepsis. This leads to severe damage to the intestinal barrier and integrity. It is hypothesized that this transmural injury will lead to release of smooth muscle cell proteins like transgelin. Indeed, it has been shown that elevated levels of transgelin have been found in patients with transmural ischemia compared to controls. The diagnosis of leiomyosarcoma is clinically important because it has been reported that soft tissue sarcomas showing a myoid differentiation, most often a smooth muscle differentiation, are more aggressive than those with no myoid differentiation. Transgelin correlates with smooth muscle differentiation. It was found that transgelin was one of the most represented in leiomyosarcomatous differentiation. |
| Immunogen | Purified SM22 from pig stomach |
| Other Names | SM-22, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SMCC, TAGLN1, WS3-10, SM22-alph, SM22 |
| Gene, Accession # | n/a |
| Catalog # | HM2405-20UG |
| Price | $157 |
| Order / More Info | Transgelin, Human Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
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