C5aR, Human Antibody from HYCULT BIOTECH
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| Antigenic Specificity | C5aR, Human |
| Clone | S5/1 |
| Host Species | Mouse |
| Reactive Species | human, rabbit |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 100 µg |
| Concentration | n/a |
| Applications | Flow cytometry, Frozen sections, Functional studies, Paraffin sections, Western blot. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody S5/1 recognizes the human receptor for C5a (CD88). The C5a receptor- is a seven transmembrane GTP-binding-protein-coupled receptor of 45kDa which binds with high affinity to human anaphylatoxin C5a. Upon C5a binding- G-protein-dependent cellular- responses are initiated such as increased intracellular Ca2+, granule fusion with the cell membrane, enzyme release and oxidative burst suggesting that C5aR is an important mediator of inflammation. The C5a receptor is expressed on a broad range of cell types, including- neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. Interestingly, C5a receptor signalling has been associated with several inflammatory diseases including rheumatoid arthritis.- Clone S5/1 was raised against a synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31). The antibody has been shown to inhibit the binding of C5a to its receptor. |
| Immunogen | Synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31) |
| Other Names | Complement component 5a receptor 1, CD88, C5aR, C5a anaphylatoxin receptor. |
| Gene, Accession # | n/a |
| Catalog # | HM2094-100UG |
| Price | $602 |
| Order / More Info | C5aR, Human Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
Profile of HYCULT BIOTECH