Allergin-1, Mouse Antibody from HYCULT BIOTECH

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Antigenic SpecificityAllergin-1, Mouse
CloneTX83
Host SpeciesMouse
Reactive Speciesmouse
IsotypeIgG1
Formatunconjugated
Size20 µg
Concentrationn/a
ApplicationsFlow cytometry. RUO
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DescriptionMonoclonal antibody clone Tx83 recognizes mouse allergy inhibitory receptor-1 (Allergin-1; also known as mast cell antigen AG-32). It is an immune regulatory molecule predominantly expressed on mast cells, but also found on other myeloid cells like macrophages, dendritic cells and neutrophils. The receptor consist of an immunoreceptor tyrosine-based inhibitory motif (ITIM) like domain. It's main function is to suppress IgE (FcεRI-) mediated degradation and TLR2- mediated signaling in mast cells. Thereby inhibiting production of cytokines and other inflammatory mediators. Allergin-1 is tyrosine phosphorylated and recruits SH2 phosphatases , such as SHP-1, SHP-2 or SHIP. Co-ligation with FcεRI decreases mast cell degranulation. Currently three isoforms of human allergin-1 are identified: allergin-1L, Allergin-1S1 & allergin-1S2. Mast cells play a pivotal role in allergic reactions in barrier tissues, like skin and intestinal mucosa. Allergin-1 is suggested to play a role in skin diseases like dermatitis, the autoimmune diseases such as SLE and airway hyperresponsiveness. In macrophages it is suggested to play a role by suppressing autoantibody production via the promotion of apoptotic cell clearance.
ImmunogenTX83 was generated by immunizing Allergin-1-deficient mice with BW5147 transfectants expressing Flag-tagged Allergin-1.
Other Namesallergy inhibitory receptor-1 , mast cell antigen AG-32
Gene, Accession #n/a
Catalog #HM1143-20UG
Price$157
Order / More InfoAllergin-1, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
HYCULT BIOTECH
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353

info@hycultbiotech.com

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