Activated C1s, Human Antibody from HYCULT BIOTECH

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Antigenic SpecificityActivated C1s, Human
CloneM241
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentrationn/a
ApplicationsFlow cytometry, Frozen sections, Functional studies, Immuno assays, Immuno precipitation, Paraffin sections, Western blot. RUO
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DescriptionMonoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM2109-100UG
Price$602
Order / More InfoActivated C1s, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
HYCULT BIOTECH
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353

info@hycultbiotech.com

https://www.hycultbiotech.com

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