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Antigenic Specificity | CD11b, Human |
Clone | Bear-1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 20 µg |
Concentration | n/a |
Applications | Flow cytometry, Frozen sections. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD11b is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated. Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex. |
Immunogen | n/a |
Other Names | CR3, Mac-1, Mo-1 in integrin alphaM |
Gene, Accession # | n/a |
Catalog # | HM2125F-20UG |
Price | $157 |
Order / More Info | CD11b, Human Antibody from HYCULT BIOTECH |
Product Specific References | n/a |