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Antigenic Specificity | C5L2, Human |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 20 µg |
Concentration | n/a |
Applications | Flow cytometry, Frozen sections, Immuno fluorescence, Western blot. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The orphan receptor C5L2/pgpr77, which shares 35% amino identity with CD88, is a promiscuous complement fragment-binding protein. C5L2 binds C5a with high affinity but has a 10-fold higher affinity for C5adR than CD88. C5L2 also has an affinity for C4a and C3a, and their metabolites C4a des-Arg, and C3a des-Arg. C3a binds at a site distinct from the C5a binding site. C5L2 transfected into cells does not support degranulation or increases in intracellular [Ca2+] and is not rapidly internalized in response to ligand binding. However, ligation of C5L2 by anaphylatoxin potentiates the degranulation response to cross-linkage of the high affinity IgE receptor suggesting that C5L2 is an anaphylatoxin-binding protein with unique ligand binding and signalling properties. C5L2 is proposed to mediate the acylation-stimulating properties of C3a des-Arg/ASP. C5L2 is expressed in granulocytes, in mature dendritic cells, adipose tissue and fibroblasts. |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | HP9036-20UG |
Price | $157 |
Order / More Info | C5L2, Human Antibody from HYCULT BIOTECH |
Product Specific References | n/a |