SIGN-R1, Mouse Antibody from HYCULT BIOTECH
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| Antigenic Specificity | SIGN-R1, Mouse |
| Clone | ER-TR9 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgM |
| Format | unconjugated |
| Size | 200 µg |
| Concentration | n/a |
| Applications | Flow cytometry, Frozen sections, Functional studies. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages. |
| Immunogen | Mouse thymic stromal cells |
| Other Names | CD209b, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 |
| Gene, Accession # | n/a |
| Catalog # | HM1080-1ML |
| Price | $488 |
| Order / More Info | SIGN-R1, Mouse Antibody from HYCULT BIOTECH |
| Product Specific References | n/a |
HYCULT BIOTECH
HYCULT BIOTECH
Frontstraat 2a
5405 PB Uden THE NETHERLANDS
P: +31 (0)413 251335
F: +31 (0)413 248353
info@hycultbiotech.com
https://www.hycultbiotech.com
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