Human Hepsin Antibody from ICHORBIO
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| Antigenic Specificity | Human Hepsin |
| Clone | 2D5-1.9 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 25mg |
| Concentration | 1.0 - 5.0 mg/ml |
| Applications | ELISA, FC, WB. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Clone 2D5 recognizes Human hepsin. It binds to a separate epitope than clone 3H10.1. These clones do not interfere with one another. Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.6 |
| Immunogen | Human hepsin protein |
| Other Names | Serine protease hepsin, hpn |
| Gene, Accession # | UniProt: P05981 |
| Catalog # | ICH1160UL-25mg |
| Price | $1500 |
| Order / More Info | Human Hepsin Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
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