Human CD2 Antibody from ICHORBIO
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| Antigenic Specificity | Human CD2 |
| Clone | LO-CD2a |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 50mg |
| Concentration | ≥ 2.0 mg/ml |
| Applications | ELISA, Functional Assays, Flow Cytometry. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-CD2 antibody (clone LO-CD2a) activity is directed against human CD2. LO-CD2a strongly inhibits mixed lymphocyte culture (MLC) 3 and induces T cell apoptosis. Additionally, LO-CD2a does not induce proliferation of resting T cells, and inhibits T cell proliferation induced by OKT3 antibody, induces very low levels of cytokine release, and also inhibits cytokine production induced by OKT3, LO-CD2a strongly inhibits proliferation of peripheral blood mononuclear cells stimulated with soluble OKT3, and induces human T cell hyporesponsiveness. Adding LO-CD2a to a primary MLC inhibits the T cell proliferation response and has a subsequent inhibitory effect on the secondary immune response, thereby blocking primary and memory alloantigen proliferative responses. The human T cell hyporesponsiveness in the secondary MLC is restricted to alloantigens and occurs both in the absence of antibody and after cell surface re-expression of CD2 |
| Immunogen | LO-CD2a was developed as an immunosuppressive agent for use in organ allotransplantation. LO-CD2a was produced by immunizing a LOU/C rat with purified human T lymphocytes and fusing the splenocytes with the non-secreting rat fusion cell line IR983F, resulting in a rat IgG2b mAb of the IgK-1a allotype |
| Other Names | BTI-322, CD2, CD2 molecule, T11, SRBC, LFA-2, T-cell surface antigen CD2, LFA-3 receptor, rosette receptor, erythrocyte receptor, lymphocyte-function antigen-2, T-cell surface antigen T11/Leu-5, CD2 antigen (p50), sheep red blood cell receptor |
| Gene, Accession # | n/a |
| Catalog # | ICH1193-50mg |
| Price | $1775 |
| Order / More Info | Human CD2 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
Boston House, Grove Business Park
Downsview Road
Wantage OX12 9FF ENGLAND
orders@ichor.bio
https://ichor.bio
U.S. OFFICE
987 Old Eagle School Rd, Ste 709
Wayne, PA 19087
us@ichor.bio
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