Mouse Galectin-9 Antibody from ICHORBIO
Search, find, compare suppliers for anti-Mouse Galectin-9 antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse Galectin-9 |
| Clone | RG9-1 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 25mg |
| Concentration | ≥ 5.0 mg/ml |
| Applications | Blocking. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: RG9-1 activity is directed against mouse galectin-9. Galectin-9 (Gal-9), a member of the galectin family of mammalian lectins, binds β-galactoside. Gal-9 is expressed by many cell types, including endothelial cells, the epithelium of the gastrointestinal tract, T cells, B cells, macrophages, and mast cells. Gal-9 plays a significant role in innate and adaptive immunity and regulates excessive immunity by suppressing interleukin (IL)-17 producing effector T helper cells (Th)17 and Th1 as well as by augmenting Foxp3+ regulatory T cells (Treg). In addition, Gal-9 induces monocytic myeloid-derived suppressor cells (MDSCs), granulocytic MDSCs, and plasmacytoid dendritic cell-like macrophages. Gal-9 also suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Additionally, Gal-9 stimulates the maturation of dendritic cells.Gal-9 is thought to function by binding to specific carbohydrate moieties in receptor molecules expressed on the surface of its target cells, including the T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3)1. Gal-9 is predominantly located in the cytoplasm but can also be secreted. Gal-9 is expressed by a variety of tumor cells, plays a role in tumor immunity, and can suppress tumor metastasis by blocking adhesion to endothelium and extracellular matrices. CD45, which regulates antigen receptor signaling, is a major glycoprotein receptor for Gal-9 on naive B cells. |
| Immunogen | Recombinant mouse galectin-9 |
| Other Names | Gal-9 |
| Gene, Accession # | UniProt: O08573 |
| Catalog # | ICH1186-25mg |
| Price | $1100 |
| Order / More Info | Mouse Galectin-9 Antibody from ICHORBIO |
| Product Specific References | n/a |
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