Mouse CD27 Antibody from ICHORBIO
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| Antigenic Specificity | Mouse CD27 |
| Clone | RM27-3E5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG1 kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 100mg |
| Concentration | ≥ 5.0 mg/ml |
| Applications | Functional Assays, Flow Cytometry, ImmunoPrecipitation. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: RM27-3E5 activity is directed against mouse CD27. CD27 is a glycosylated, type I transmembrane protein of the TNFR superfamily that is constitutively expressed on the surface of progenitor and naive T cells as well as subsets of natural killer (NK) and B cells. CD27 is an immune-checkpoint receptor and ligation with CD70 results in co-stimulatory effects that enhance primary, memory, and recall T cell responses. CD27 signaling has been targeted for the development of viral, autoimmune, and anti-tumor immunotherapies.RM27-3E5 (rat IgG2a) was raised against recombinant mouse CD27-human IgG1 Fc fusion protein and purified from ascites using protein G columns. RM27-3E5 enhances anti-CD3-stimulated T cell proliferation when immobilized in vitro and augments ovalbumin-specific cytotoxic T lymphocyte (CTL) induction when administered in vivo.RM27-3E5 is an agonistic antibody and has been found to support the control of both established lung metastases and subcutaneous tumors. An anti-tumor effect was also observed with RM27-3E5 against EG7/CD27(+) and EG7/CD27(−) tumors, with the effect mediated mainly by T cells with a minor contribution by NK cells. RM27-3E5 exerts its potent anti-tumor effect by inducing a tumor-specific CTL response. RM27-3E5 has potential utility as a non-depleting agonistic anti-CD27 mAb to enhance anti-tumor immunity |
| Immunogen | Mouse CD27-human IgG1 Fc fusion protein |
| Other Names | CD27L receptor, Tnfrsf7 |
| Gene, Accession # | UniProt: P41272 |
| Catalog # | ICH1185-100mg |
| Price | $2600 |
| Order / More Info | Mouse CD27 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
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