Mouse ICOS Antibody from ICHORBIO
Search, find, compare suppliers for anti-Mouse ICOS antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse ICOS |
| Clone | 7E.17G9 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b |
| Format | Protein A/G purified, low endotoxin |
| Size | 100mg |
| Concentration | 1.0 - 5.0 mg/ml |
| Applications | Western Blot, Blocking, Functional Assays, Flow Cytometry. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) recognizes an epitope on Mouse ICOS. Inducible co-stimulator (ICOS), also called ALIM and H4, is a homodimeric protein and member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T cell surface, does not up-regulate the production of IL-2, but superinduces the synthesis of IL-10, a B cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B cell maturation. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. It is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases. |
| Immunogen | n/a |
| Other Names | Inducible T-cell costimulator, Icos, Activation-inducible lymphocyte immunomediatory molecule, CD28 and CTLA-4-like protein, CCLP, CD28-related protein 1, CRP-1, Ailim, CD278 |
| Gene, Accession # | UniProt: Q9WVS0 |
| Catalog # | ICH1082-100mg |
| Price | $2600 |
| Order / More Info | Mouse ICOS Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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