Human CD20 Antibody from ICHORBIO
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| Antigenic Specificity | Human CD20 |
| Clone | 2H7 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 50mg |
| Concentration | 1.0 - 5.0 mg/ml |
| Applications | Flow Cytometry, CyTOF, IHC (Frozen), Immunoprecipitation. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-CD20 In Vivo Antibody - Low Endotoxin (2H7) recognizes an epitope on Human CD20. The CD20 antigen, also called MS4A1, B1 and Bp35, is a non-glycosylated, transmembrane spanning, phosphoprotein. The CD20 protein is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells, and is synchronous with the expression of surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. CD20 has been shown to be heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. Extensive CD20 cross-linking may also influence cell death by apoptosis. Therapy with antibodies against CD20 is a widely used regimen in the treatment of all B cell lymphomas and leukemias. |
| Immunogen | n/a |
| Other Names | B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1 |
| Gene, Accession # | UniProt: P11836 |
| Catalog # | ICH1012-50mg |
| Price | $1775 |
| Order / More Info | Human CD20 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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Wantage OX12 9FF ENGLAND
orders@ichor.bio
https://ichor.bio
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987 Old Eagle School Rd, Ste 709
Wayne, PA 19087
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