Human CXCR4 Antibody from ICHORBIO
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| Antigenic Specificity | Human CXCR4 |
| Clone | 12G5 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 5mg |
| Concentration | ≥ 2.0 mg/ml |
| Applications | Blocking, Flow Cytometry, Immunocytochemistry, Immunofluorescence Microscopy, Immunohistochemistry, Neutralization, Western Blotting. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: 12G5 activity is directed against human CXCR4 (CD184; Fusin). 12G5 binds specifically to both human and nonhuman cells that express recombinant CXCR4. 12G5 inhibits CD4-independent infection by some HIV-2 isolates, and preincubating cells with 12G5 abolishes syncytium formation. HIV-2/vcp-infected cells display a marked and selective reduction in 12G5 binding. 12G5 also inhibits induction of cell-to-cell fusion of CXCR4+ RD/CD4 cells by HIV-1 and HIV-2 strains. |
| Immunogen | 12G5 was produced by immunizing Balb/c mice with CP-MAC-infected Sup-T1 cells. Hybridomas were generated and screened for the ability to inhibit CP-MAC-induced syncytium induction on Sup-T1 cells. |
| Other Names | Fusin, LESTR, CD184 |
| Gene, Accession # | n/a |
| Catalog # | ICH1199-5mg |
| Price | $375 |
| Order / More Info | Human CXCR4 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
Boston House, Grove Business Park
Downsview Road
Wantage OX12 9FF ENGLAND
orders@ichor.bio
https://ichor.bio
U.S. OFFICE
987 Old Eagle School Rd, Ste 709
Wayne, PA 19087
us@ichor.bio
Profile of ICHORBIO