Human CCR5 Antibody from ICHORBIO

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Antigenic SpecificityHuman CCR5
CloneHEK/1/85a/7a
Host SpeciesRat
Reactive Specieshuman
IsotypeIgG2b kappa
FormatProtein A/G purified, low endotoxin
Size25mg
Concentration≥ 5.0 mg/ml
ApplicationsFlow Cytometry, ImmunoCytochemistry. RUO
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DescriptionSpecificity: Clone HEK/1/85a/7a recognizes an epitope on human CCR5. CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
ImmunogenCHO cells transfected with full-length human CD195 (CCR5).
Other NamesC-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, CD195
Gene, Accession #UniProt: P51681
Catalog #ICH1172-25mg
Price$1100
Order / More InfoHuman CCR5 Antibody from ICHORBIO
Product Specific Referencesn/a
ICHORBIO
ICHORBIO
ICHORBIO
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Wantage OX12 9FF ENGLAND

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