Mouse CD40 Antibody from ICHORBIO
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| Antigenic Specificity | Mouse CD40 |
| Clone | FGK4.5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a |
| Format | Protein A/G purified, low endotoxin |
| Size | 5mg |
| Concentration | > 2.0 mg/ml |
| Applications | Western Blot, Functional Assays, Flow Cytometry. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-CD40 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) recognizes an epitope on Mouse CD40. CD40, also known as TNFSF5, is a type I transmembrane protein and member of the TNF receptor family. The binding of CD40L (CD154) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. Some of the early intracellular signaling by the CD4-CD40L system includes the association of the CD40 with TRAFs and the activation of various kinases (4). Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of CD4-CD40L is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
| Immunogen | Recombinant Mouse CD40 Fusion Protein |
| Other Names | n/a |
| Gene, Accession # | UniProt: P27512 |
| Catalog # | ICH1073UL-5mg |
| Price | $470 |
| Order / More Info | Mouse CD40 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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Downsview Road
Wantage OX12 9FF ENGLAND
orders@ichor.bio
https://ichor.bio
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987 Old Eagle School Rd, Ste 709
Wayne, PA 19087
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