Mouse CD115 Antibody from ICHORBIO

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Antigenic SpecificityMouse CD115
CloneAFS98
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a kappa
FormatProtein A/G purified, low endotoxin
Size25mg
Concentration1.0 - 5.0 mg/ml
ApplicationsWestern Blot, Blocking, Functional Assays, Flow Cytometry. RUO
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DescriptionSpecificity: Anti-CD115 In Vivo Antibody - Low Endotoxin (AFS98) recognizes an epitope on Mouse M-CSFR. Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. It also triggers growth and development of mononuclear phagocytes and placental trophoblasts. M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion.
ImmunogenPurified Recombinant Mouse M-CSFR
Other NamesMacrophage colony-stimulating factor 1 receptor, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, Csf1r, Csfmr, Fms
Gene, Accession #UniProt: P09581
Catalog #ICH1068-25mg
Price$1100
Order / More InfoMouse CD115 Antibody from ICHORBIO
Product Specific Referencesn/a
ICHORBIO
ICHORBIO
ICHORBIO
Boston House, Grove Business Park
Downsview Road
Wantage OX12 9FF ENGLAND

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