Mouse CD28 Antibody from ICHORBIO
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| Antigenic Specificity | Mouse CD28 |
| Clone | 37.51 |
| Host Species | Syrian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | purified, low endotoxin |
| Size | 25mg |
| Concentration | 1.0 - 5.0 mg/ml |
| Applications | Immunoprecipitation, Western Blot, Blocking, Functional Assays, Flow Cytometry, IHC (Frozen). RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-CD28 In Vivo Antibody - Ultra Low Endotoxin (37.51) recognizes the CD28 co-stimulatory receptor, a ligand of CD80 (B7-1) and CD86 (B7-2). CD28 is important for transmitting co-stimulatory signals for optimal T-cell activation. CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. It is expressed on the cell surface as disulfide-linked homodimer or as monomer. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. Stimulation through CD28 in addition to the TCR can provide a potent co-stimulatory signal to T cells for the production of various interleukins (IL-2 and IL-6 in particular). CD28 possesses an intracellular domain with several residues that are critical for its effective signalling. CD28 also contains two proline-rich motifs that are able to bind SH3-containing proteins. CD28 has also been found to stimulate eosinophil granulocytes where its ligation with anti-CD28 leads to the release of IL-2, IL4, IL-13 and IFN-γ. |
| Immunogen | C57BL/6 mouse T-cell lymphoma EL-4 |
| Other Names | n/a |
| Gene, Accession # | UniProt: P31041 |
| Catalog # | ICH1055UL-25mg |
| Price | $1500 |
| Order / More Info | Mouse CD28 Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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Wantage OX12 9FF ENGLAND
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https://ichor.bio
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Wayne, PA 19087
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