Mouse Fas Ligand Antibody from ICHORBIO
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| Antigenic Specificity | Mouse Fas Ligand |
| Clone | MFL3 |
| Host Species | Armenian Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | Protein A/G purified, low endotoxin |
| Size | 5mg |
| Concentration | ≥ 5.0 mg/ml |
| Applications | Blocking, Flow Cytometry, Immunofluorescence. RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Clone MFL3 recognizes an epitope on mouse FasL. FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand. FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily. FasL is expressed by activated T cells and natural killer (NK cells). Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity. FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death. FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites. FasL also contributes to CD8 proliferation and neutrophil recruitment. Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling. Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer. Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis. |
| Immunogen | B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells |
| Other Names | FasL, Apo-1 Ligand, CD95 Ligand, TNFSF6, CD178 |
| Gene, Accession # | UniProt: P41047 |
| Catalog # | ICH1178-5mg |
| Price | $375 |
| Order / More Info | Mouse Fas Ligand Antibody from ICHORBIO |
| Product Specific References | n/a |
ICHORBIO
ICHORBIO
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