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Antigenic Specificity | Mouse IL-1R |
Clone | JAMA-147 |
Host Species | Armenian Hamster |
Reactive Species | mouse |
Isotype | IgG |
Format | Protein A/G purified, low endotoxin |
Size | 50mg |
Concentration | 1.0 - 5.0 mg/ml |
Applications | Immunoprecipitation, Western Blot, Blocking, Flow Cytometry. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147) recognizes Mouse IL-1 R1. IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1alpha and IL-1beta exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein. |
Immunogen | Extracellular domain of mouse IL-1 R type 1 |
Other Names | Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha,IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a |
Gene, Accession # | UniProt: P13504 |
Catalog # | ICH1117-50mg |
Price | $1775 |
Order / More Info | Mouse IL-1R Antibody from ICHORBIO |
Product Specific References | n/a |
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