Mouse RANKL Antibody from ICHORBIO
Search, find, compare suppliers for anti-Mouse RANKL antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse RANKL |
| Clone | IK22/5 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a kappa |
| Format | Protein A/G purified, low endotoxin |
| Size | 5mg |
| Concentration | 1.0 mg/ml |
| Applications | Flow Cytometry, Immunoprecipitation, Western Blot, Blocking, Immunofluorescence, IHC (Frozen). RUO |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) recognizes an epitope on Mouse RANKL. RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a member of the tumor necrosis factor family cytokine. RANKL is essential for osteoclast formation, activation, and survival. RANKL through interaction with its receptor RANK can modulate matrix degradation and inflammation. RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy. Consequently, novel drugs specifically targeting RANK, RANKL, and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various ailments associated with bone loss, such as arthritis, periodontal disease, cancer metastases, and osteoporosis. |
| Immunogen | Purified Recombinant Mouse RANKL (NSO-derived) |
| Other Names | Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254 |
| Gene, Accession # | UniProt: O35235 |
| Catalog # | ICH1114UL-5mg |
| Price | $470 |
| Order / More Info | Mouse RANKL Antibody from ICHORBIO |
| Product Specific References | A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin: https://www.nature.com/articles/s41467-022-32435-5 |
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