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Antigenic Specificity | CD14 (Atibuclimab biosimilar) |
Clone | monoclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | IgG4 |
Format | Protein A/G purified, low endotoxin |
Size | 5mg |
Concentration | 5mg/ml |
Applications | Functional Assays. RUO |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: detects human CD14. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Atibuclimab. RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra. |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | UniProt: P08571 |
Catalog # | ICH5016-5mg |
Price | $718 |
Order / More Info | CD14 (Atibuclimab biosimilar) Antibody from ICHORBIO |
Product Specific References | n/a |
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