VR1 / TRPV1 Antibody from LIFESPAN BIOSCIENCES INC.

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Antigenic SpecificityVR1 / TRPV1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatbiotin conjugate
Size50 µg
Concentrationn/a
ApplicationsELISA
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DescriptionVR1 / TRPV1 Antibody (Biotin) LS-C501370. Specificity: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
ImmunogenRecombinant Human Transient receptor potential cation channel subfamily V member 1 protein (1-155AA)
Other NamesTRPV1, Capsaicin receptor, OTRPC1, Vanilloid receptor subtype 1, Osm-9-like TRP channel 1, Vanilloid receptor 1, VR1
Gene, Accession #TRPV1, Gene ID: 7442
Catalog #LS-C501370-50
Priceplease inquire
Order / More InfoVR1 / TRPV1 Antibody from LIFESPAN BIOSCIENCES INC.
Product Specific Referencesn/a
LIFESPAN BIOSCIENCES INC.
LIFESPAN BIOSCIENCES INC.
LIFESPAN BIOSCIENCES INC.
2401 Fourth Avenue, Suite 900
Seattle WA 98121
P: 206-374-1102
P: 866-819-4732 (toll free N. America)
F: 206-577-4565

customer.support@lsbio.com
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