CTNNB1 / Beta Catenin Antibody from LSBio

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Antigenic SpecificityCTNNB1 / Beta Catenin
CloneCTNNB1/2030R
Host SpeciesRecombinant Rabbit
Reactive Specieshuman
IsotypeIgG
FormatProtein A purified
Size100 µg
Concentrationn/a
ApplicationsFlo, IF, IHC-P, WB
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DescriptionSpecificity: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Immunogenn/a
Other NamesCTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin
Gene, Accession #CTNNB1, Gene ID: 1499
Catalog #LS-B16275-100
Price$495
Order / More InfoCTNNB1 / Beta Catenin Antibody from LSBio
Product Specific Referencesn/a
LSBio
LSBio
LSBio
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