NUPR1 Antibody from LSBio
Search, find, compare suppliers for anti-NUPR1 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | NUPR1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 50 µg |
| Concentration | n/a |
| Applications | ELISA, IF, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. |
| Immunogen | n/a |
| Other Names | NUPR1, Candidate of metastasis 1, Nuclear protein 1, p8, Protein p8, COM1 |
| Gene, Accession # | NUPR1, Gene ID: 26471 |
| Catalog # | LS-C500644-50 |
| Price | $294 |
| Order / More Info | NUPR1 Antibody from LSBio |
| Product Specific References | n/a |
LSBio
LSBio
An Absolute Biotech Company
2 Shaker Road, Unit B101
Shirley MA 01464
P: 206-374-1102
P: 866-819-4732 (toll free N. America)
F: 206-577-4565
customer.support@lsbio.com
Orders: Orders@LSBio.com
Tech Support: Technical.Support@LSBio.com
http://www.LSBio.com
Profile of LSBio
Return to Antibodies