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Antigenic Specificity | CDH1 / E Cadherin |
Clone | rCDH1/1525 |
Host Species | Recombinant Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein A/G purified |
Size | 100 µg |
Concentration | n/a |
Applications | IF, IHC-P, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Recognizes a protein of 120-80 kDa , identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Does not react with: Mouse, Rat |
Immunogen | n/a |
Other Names | CDH1, CD324, CDHE, Cell-CAM 120/80, E Cadherin, E-Cadherin, ECAD, Epithelial cadherin, Arc-1, UVO, Cadherin-1, CAM 120/80, CD324 antigen, LCAM, Uvomorulin |
Gene, Accession # | CDH1, Gene ID: 999 |
Catalog # | LS-B16237-100 |
Price | $495 |
Order / More Info | CDH1 / E Cadherin Antibody from LSBio |
Product Specific References | n/a |