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Antigenic Specificity | BCL6, aa256-389 |
Clone | rBCL6/1718 |
Host Species | Recombinant Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | Protein A/G purified |
Size | 100 µg |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Recognizes a protein of 95 kDa , which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma. |
Immunogen | n/a |
Other Names | BCL6, BCL6A, BCL-5, BCL5, Protein LAZ-3, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL-6, Zinc finger protein 51 |
Gene, Accession # | BCL6, Gene ID: 604 |
Catalog # | LS-C751349-100 |
Price | $560 |
Order / More Info | BCL6, aa256-389 Antibody from LSBio |
Product Specific References | n/a |