IL-12R β2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-12R β2, Human |
| Clone | REA333 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-12R β2 Antibody, anti-human, Biotin, REAfinity™. Clone REA333 recognizes the human interleukin 12 (IL-12) receptor subunit beta-2 (IL-12R β2) antigen, a single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon γ. IL-12R β2 is expressed by T?1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued T?1 differentiation. The IL-12R β2 subunit plays an important role in T?1 cell differentiation, since its absence leads to an abortive T?1 differentiation that has dysfunctional production of T?1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. | Additional information: Clone REA333 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | IL12RB2 |
| Gene, Accession # | Gene ID: 3595 |
| Catalog # | 130-104-982 |
| Price | $260 |
| Order / More Info | IL-12R β2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in T?1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 169 (8): 4388-4398. | Salomon, D. R. et al. (2017) H3K27 methylation dynamics during CD4 T cell activation: regulation of JAK/STAT and IL12RB2 Eexpression by JMJD3. J Immunol 199 (9): 3158-3175. | Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J Immunol 164 (6): 3056-3064. | Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002-14007. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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