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Antigenic Specificity | CD163, Human |
Clone | GHI/61.1 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG1κ |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, Immunohistochemistry, Immunofluorescence, MICS (MACSima Imaging Cyclic Staining) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD163 Antibody, anti-human, PE. The monoclonal antibody GHI/61.1 reacts with human CD163, a single-chain transmembrane protein also known as hemoglobin scavenger receptor or M130. It is expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated in vitro and in vivo by anti-inflammatory mediators such as IL-10 and (gluco)corticosteroid and is shed to blood upon inflammatory activation of macrophages. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin. Depending on the ligand, crosslinking of M130 initiates signal transduction leading to the production of proinflammatory cytokines Il-1β, IL-6, and GM-CSF or the antiinflammatory cytokine IL-10. |
Immunogen | n/a |
Other Names | GHI/61, M130, MM130, CD163 |
Gene, Accession # | Gene ID: 9332 |
Catalog # | 130-123-249 |
Price | $310 |
Order / More Info | CD163, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Kristiansen, M. et al. (2001) Identification of the haemoglobin scavenger receptor. Nature 409 (6817): 198-201. | Law, S. K. et al. (1993) A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur. J. Immunol. 23 (9): 2320-2325. | Ritter, M. et al. (2001) Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur. J. Immunol. 31 (4): 999-1009. | Pulford, K. et al. (1992) A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology 75 (4): 588-595. | Burdo, T. H. et al. (2011) Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J. Infect. Dis. 204: 154-163. |