CD133/2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD133/2, Human |
| Clone | AC141 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD133/2 Antibody, anti-human, PE. CD133 is a novel 5-transmembrane cell surface antigen with a molecular weight of 117 kDa. CD133/2 (AC141) antibodies recognize epitope 2 of the human CD133 antigen (CD133/2). In the hematopoietic system, CD133 expression is restricted to a subset of CD34bright stem and progenitor cells in human fetal liver, bone marrow, cord blood and peripheral blood. Additionally, CD133 is expressed by a small portion of CD34- cells in these tissues. The CD34+CD133+ cell population, which includes CD34+CD38- cells, was shown to be capable of repopulating NOD/SCID mice. Recently, CD133 has also been found to be expressed on endothelial precursor cells and fetal neural stem cells as well as on developing epithelium. The putative murine homologue, prominin, which is expressed on neuroepithelial and epithelial mouse cells, was identified. In contrast to the other CD133 clones, the clone AC141 shows cross-reactivity with the intracellular protein cytokeratin 18. |
| Immunogen | n/a |
| Other Names | PROM1, AC133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 |
| Gene, Accession # | Gene ID: 8842 |
| Catalog # | 130-120-145 |
| Price | $119 |
| Order / More Info | CD133/2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Miraglia, S. et al. (1997) A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90 (12): 5013-5021. | Yin, A. H. et al. (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012. | Gallacher, L. et al. (2000) Isolation and characterization of human CD34-Lin- and CD34+Lin- hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 95 (ARVO Annual Meeting Abstract): 2813-2820. | Gehling, U. M. et al. (2000) In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 95: 3106-3112. | Peichev, M. et al. (2000) Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 95: 952-958. | Uchida, N. et al. (2000) Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. U.S.A. 97: 14720-14725. | Weigmann, A. et al. (1997) Prominin, a novel microvilli-specific polytopic membrane proteine of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 94: 12425-12430. | Buhring, H. J. et al. (1999) Expression of novel surface antigens on early hematopoietic cells. Ann. N. Y. Acad. Sci. 872: 25-39. | Lai, J. et al. (2014) Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice. Int. J. Oncol. 44 (5): 1481-1489. | Corbeil, D. et al. (2000) The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. J. Biol. Chem. 275: 5512-5520. | Piechaczek, C. (2001) CD133. J. Biol. Regul. Homeost. Agents 15: 101-102. | Potgens, A. J. et al. (2002) Monoclonal antibody CD133-2 (AC141) against hematopoietic stem cell antigen CD133 shows crossreactivity with cytokeratin 18. J. Histochem. Cytochem. 50 (8): 1131-1134. | de Wynter, E. A. et al. (1998) CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells 16: 387-396. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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