CD244 (2B4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD244 (2B4), Human |
| Clone | REA112 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD244 (2B4) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA112 recognizes CD244, a type I transmembrane receptor belonging to the CD2 subfamily of the Ig superfamily. Expression of CD244 is found on all natural killer (NK) cells, large subset of CD8+ T cells, a small fraction of CD4+ T cells, and eosinophils. Human CD244 upon ligand engagement activates NK cell cytotoxicity and production of interferon gamma (IFN-γ). Activating function of human CD244 requires recruitment of SH2 domain containing molecule called SLAM associated protein (SAP). In humans, CD244 has also been implicated as an inhibitory receptor such as in developing NK cells. In contrast, murine CD244 is primarily involved in inhibiting NK cell functions. Two isoforms of human CD244 exist on NK cells, h2B4-A and h2B4-B, which differ in their binding affinity to ligand CD48. | Additional information: Clone REA112 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | 2B4, NAIL, NKR2B4, Nmrk, SLAMF4 |
| Gene, Accession # | Gene ID: 51744 |
| Catalog # | 130-123-487 |
| Price | $345 |
| Order / More Info | CD244 (2B4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Munitz, A. et al. (2005) 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol 174: 110-118. | Sivori, S. et al. (2002) Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. U.S.A. 99: 4526-4531. | Mathew, S. O. et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur. J. Immunol. 39 (6): 1632-1641. | Vaidya, S. V. et al. (2006) Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. Immunol. Lett. 105 (2): 180-184. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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