Sca-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Sca-1, Mouse |
| Clone | D7 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2aκ |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Sca-1 Antibody, anti-mouse, Biotin. Sca-1 (stem cell antigen-1) is a 18 kDa GPI-linked surface protein of the Ly-6 family (Ly-6A/E). The Anti-Sca-1 antibody clone D7 specifically recognizes both Ly-6E.1 and Ly-6A.2, which are gene products of the two Ly-6A/E alleles expressed in different mouse strains (Ly-6E.1: e.g. BALB/c, C3H, NZB; Ly6A.2: e.g. C57BL/6, SJL, 129, AKR). | Sca-1 is expressed on hematopoietic stem cells and progenitor cells in mouse bone marrow and one of the defining markers for so-called KSL (c-kit+ Sca-1+ Lin-) cells. Sca-1 in combination with CD105 (Endoglin) expression has been used to define long-term repopulating hematopoietic stem cells (LTR-HSCs) in mouse bone marrow1,2. In addition, Sca-1+ bone marrow cells also contain the mesenchymal stem cell fraction present. Sca-1+ cells have been shown to give rise to hepatocytes in vivo 3) and neural cells in vitro. 4) Furthermore, Sca-1 is expressed on stem cells in a variety of nonhematopoietic tissues, such as adult liver 5), heart 6), and prostate. 7) | |
| Immunogen | n/a |
| Other Names | LY6A, Ly-6A.2, Ly-6A/E, Ly-6E.1, TAP |
| Gene, Accession # | Gene ID: 110454 |
| Catalog # | 130-126-949 |
| Price | $52 |
| Order / More Info | Sca-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chen, C. Z. et al. (2003) The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity 19: 525-533. | Burger, P. E. et al. (2005) Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc. Natl. Acad. Sci. U.S.A. 102: 7180-7185. | Chen, C. Z. et al. (2002) Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 99: 15468-15473. | Sanchez-Ramos, J. et al. (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp. Neurol. 164 (2): 247-256. | Petersen, B. E. et al. (2003) Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers. Hepatology 37: 632-640. | Matsuura, K. et al. (2004) Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J. Biol. Chem. 279: 11384-11391. | Lagasse, E. et al. (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6: 1229-1234. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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