H2AX pS139, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | H2AX pS139, Human/Mouse |
| Clone | REA502 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | H2AX pS139 Antibody, anti-human/mouse, Vio® B515, REAfinity™. Clone REA502 recognizes the human and mouse histone H2AX antigen phosphorylated at serine 139 (pS139). H2AX is a 14 kDa basal histone and a variant of the H2 histone family. It replaces conventional H2A in a subset of nucleosomes. When cells are exposed to ionizing radiation or DNA-damaging chemotherapeutic agents, double-stranded breaks (DSBs) are generated that rapidly result in the phosphorylation of H2AX at serine 139 (γH2AX). Because phosphorylation of H2AX is abundant, fast, and correlates well with each DSB, it is the most sensitive marker that can be used to examine the DNA damage produced and the subsequent repair of the DNA lesion. γH2AX also participates in the evolutionarily conserved process of sister chromatid recombination, a homologous recombination pathway involved in the suppression of genomic instability during DNA replication and directly implicated in tumor suppression. | Additional information: Clone REA502 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | H2AFX, H2AX, H2a/x, H2A.X, γ-H2AX, γH2AX |
| Gene, Accession # | Gene ID: 3014, 15270 |
| Catalog # | 130-130-936 |
| Price | $158 |
| Order / More Info | H2AX pS139, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Paull, T. T. et al. (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10 (15): 886-895. | Mannironi, C. et al. (1989) H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals. Nucleic Acids Res. 17 (22): 9113-9126. | Sharma, A. et al. (2012) Histone H2AX phosphorylation: a marker for DNA damage. Methods Mol. Biol. 920: 613-626. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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