I-Aq, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | I-Aq, Mouse |
| Clone | REA478 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | I-Aq Antibody, anti-mouse, Vio® Bright FITC, REAfinity™. Clone REA478 recognizes the mouse I-Aq MHC class II alloantigen. It also recognizes with I-As and I-Av.1. Reactivity with other haplotypes has not been reported. MHC (major histocompatibility complex) class II molecules are a family of molecules normally found on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. Because class II MHC is loaded with extracellular proteins, it is mainly concerned with presentation of extracellular pathogens. | Additional information: Clone REA478 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MHC class II |
| Gene, Accession # | Gene ID: 14961 |
| Catalog # | 130-107-641 |
| Price | $90 |
| Order / More Info | I-Aq, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Baumgart, M. et al. (1998) Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6936-6940. | Backlund, J. et al. (2013) C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann. Rheum. Dis. 72 (7): 1225-1232. | Ishimaru, N. et al. (2018) CCL22-producing resident macrophages enhance T cell response in Sjogren's syndrome. Front Immunol 9: 2594. | Brand, D. D. et al. (2001) I-Aq and I-Ap bind and present similar antigenic peptides despite differing in their ability to mediate susceptibility to autoimmune arthritis. Autoimmunity 34 (2): 133-145. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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