Arginase-1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Arginase-1, Human |
| Clone | REAL1137 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Arginase-1 Antibody, anti-human, PE, REAdye_lease™. Clone REAL1137 is an antibody fragment derived from the full Arginase-1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1137 recognizes the isoenzyme Arginase-1, also known as ARG1, which is a member of the ureohydrolase family of enzymes. Arginase-1 converts L-arginine into L-ornithine and urea, which is then converted to polyamine. This process takes place primarily in the liver and, to a lesser extent, in the kidneys. Arginase -1 is also expressed in granulocytes, neural stem cells, and in myeloid derived suppressor cells (MDSC) and plays a role in the antimicrobial effector pathway in polymorphonuclear granulocytes. Mutations, which cause Arginase deficiency, can lead to defects in the urea cycle with hyperammonaemia. Arginase-1 is reported to be expressed in colorectal cancer and is found in the majority of hepatocellular carcinomas. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | Arginase 1, Liver-type arginase, ARG1 |
| Gene, Accession # | n/a |
| Catalog # | 130-127-839 |
| Price | $460 |
| Order / More Info | Arginase-1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Wu, G. et al. (1998) Arginine metabolism: nitric oxide and beyond. Biochem. J. 336 (Pt 1): 1-17. | Oberlies, J. et al. (2009) Regulation of NK cell function by human granulocyte arginase. J Immunol 182 (9): 5259-5267. | You, J. et al. (2018) The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma. Biomed Res Int: 2109865. | Ma, Z. et al. (2019) Overexpression of Arginase-1 is an indicator of poor prognosis in patients with colorectal cancer. Pathol Res Pract 215 (6): 152383. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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