Podoplanin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-Podoplanin, Human antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Podoplanin, Human |
| Clone | REAL468 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Podoplanin Antibody, anti-human, FITC, REAlease®. Clone REAL468 is an antibody fragment derived from the full Podoplanin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL468 recognizes the human Podoplanin antigen, a 38 to 44 kDa mucin-type transmembrane protein which is also known as E11, gp38, OTS-8, PA2.26, T1-alpha or Aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen 4 days postnatally. In adult, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate Podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. | REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. |
| Immunogen | n/a |
| Other Names | Gp36, T1A, Aggrus, PDPN, GP36, PA2.26 |
| Gene, Accession # | n/a |
| Catalog # | 130-125-009 |
| Price | $320 |
| Order / More Info | Podoplanin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Herzog, B. H. et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502 (7469): 105-109. | Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341 (Pt 2): 277-284. | Bieniasz-Krzywiec, P. et al. (2019) Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer. Cell Metab. 30 (5): 917-936. | Astarita, J. L. et al. (2012) Expression of tumor necrosis factor receptor 2 characterizes TLR9-driven formation of interleukin-10-producing B cells. Front Immunol 12 (3): 283. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG