CD8a, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD8a, Rat |
| Clone | REA437 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD8a Antibody, anti-rat, PE-Vio® 770, REAfinity™. Clone REA437 recognizes the rat CD8a antigen, a single-pass type I membrane protein, which is also known as OX-8. CD8 acts as a co-receptor for the T cell receptor and recognizes antigen displayed by an antigen presenting cell in the context of class I MHC molecules. CD8a is expressed as a heterodimer with CD8b on T cell receptor (TCR) α/β and TCR γ/δ expressing, cytotoxic T cells, and on most thymocytes. As a homodimer of two CD8a chains the CD8 antigen is expressed on most NK cells, a major fraction of intestinal intraepithelial lymphocytes, some activated CD4+CD8+ T cells and CD8+ T cells from athymic rats. CD8a is also expressed by a T cell subset with regulatory functions. | Additional information: Clone REA437 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | OX-8, Lyt2, Ly-2 |
| Gene, Accession # | Gene ID: 24930 |
| Catalog # | 130-108-913 |
| Price | $53 |
| Order / More Info | CD8a, Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Johnson, P. et al. (1985) Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes. EMBO J. 4 (10): 2539-2545. | Torres-Nagel, N. et al. (1992) Differential thymus dependence of rat CD8 isoform expression. Eur. J. Immunol. 22 (11): 2841-2848. | Strup-Perrot, C. et al. (2005) Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells. World J Gastroenterol. 11 (40): 6312-6321. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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