Notch2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Notch2, Mouse |
| Clone | HMN2-35 |
| Host Species | Hamster |
| Reactive Species | mouse |
| Isotype | IgG |
| Format | allophycocyanin (APC) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch2 Antibody, anti-mouse, APC. Clone HMN2-35 recognizes Notch2, a member of the Notch receptor family. Notch2 acts as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1. Notch signaling pathway is evolutionary conserved in the animal kingdom, where Notch receptors upon ligand binding undergo two proteolytic cleavages. The second cleavage releases the Notch intracellular domain (NICD), which translocates into the nucleus, forms an activator complex with the DNA binding protein RBP-J and activates genes of the enhancer of split locus. Notch signaling network regulates a number of biological processes involved in determination of cell fate, cell differentiation and apoptosis etc. |
| Immunogen | n/a |
| Other Names | N2 |
| Gene, Accession # | Gene ID: 18129 |
| Catalog # | 130-102-853 |
| Price | $66 |
| Order / More Info | Notch2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Maekawa, Y. et al. (2008) Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol 9 (10): 1140-1147. | Borggrefe, T. et al. (2009 ) The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell. Mol. Life Sci. 66 (10): 1631-1646. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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