CD256 (APRIL), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD256 (APRIL), Human/Mouse |
| Clone | REA347 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD256 (APRIL) Antibody, anti-human/mouse, PE-Vio® 770, REAfinity™. Clone REA347 recognizes the human and mouse CD256 antigen, a protein which is a member of the TNF ligand superfamily and also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13) or a proliferation-inducing ligand (APRIL). CD256 is expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues, and specifically expressed in monocytes and macrophages. Secreted CD256 consists almost entirely of a single TNF homology domain. Little or no transmembrane CD256 is expressed on the cell surface. CD256 binds with high affinity the TNFR family members B cell maturation antigen (BCMA) and transmembrane activator and CAML-interactor (TACI). It stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. CD256 and its receptors BCMA and TACI are involved in diseases of autoimmunity and cancer. | Additional information: Clone REA347 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April |
| Gene, Accession # | Gene ID: 8741 |
| Catalog # | 130-105-389 |
| Price | $162 |
| Order / More Info | CD256 (APRIL), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol 1 (3): 252-256. | Hahne, M. et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 188 (6): 1185-1190. | Vincent, F. B. et al. (2013) The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev. 24 (3): 203-215. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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