Integrin α7, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Integrin α7, Mouse |
| Clone | 3C12 |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | IgG1κ |
| Format | PE-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Integrin α7 Antibody, anti-mouse, PE-Vio® 770. Clone 3C12 recognizes mouse integrin alpha 7 (Itga7) which belongs to the integrin family of adhesion molecules. Integrins participate in important cell-cell and cell-extracellular matrix interactions in a diverse range of biological processes. Itga7 is a heterodimer consisting of an α and a β subunit and is mainly expressed in skeletal and cardiac muscle. It is a specific cellular receptor for the basement membrane protein laminin-1, as well as for the laminin isoforms-2 and -4 and is involved in differentiation and migration processes during myogenesis. Absence of Itga7 results in muscular dystrophy. It is also required to promote contractile phenotype acquisition in differentiated airway smooth muscle cells. |
| Immunogen | n/a |
| Other Names | Itga7, alpha7 |
| Gene, Accession # | Gene ID: 16404 |
| Catalog # | 130-103-357 |
| Price | $53 |
| Order / More Info | Integrin α7, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Liu, J. et al. (2008) Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression. Am. J. Physiol., Cell Physiol. 294: C627-C640. | Ziober, B. L. et al. (1993) Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. J. Biol. Chem. 268: 26773-26783. | Mayer, U. et al. (1997) Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat. Genet. 17 (3): 318-323. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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