Notch1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Notch1, Human |
| Clone | REA849 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch1 Antibody, anti-human, Vio® Bright B515, REAfinity™. Clone REA849 recognizes the human neurogenic locus notch homolog protein 1 (Notch1) antigen, a 300 kDa single-pass type I membrane protein also known as translocation-associated notch protein (TAN-1). Following cleavage in the Golgi, notch forms a heterodimer composed of a 180-200 kDa disulfide-linked extracellular domain (Notch extracellular truncation (NEXT)), and a 120 kDa membrane-bound intracellular portion (Notch intracellular domain (NICD)). Upon ligand binding the latter is cleaved to form the notch intracellular domain transcription factor. Notch signaling controls cell fate decisions and is involved in multiple cellular differentiation steps during embryonic development and in adult organisms. In the immune system, Notch1 plays a non-redundant role for thymic T cell development. Notch1 is also expressed by peripheral T cells and upregulated upon T cell activation and also found on bone marrow hematopoietic stem cells, NK cells, B cells, and monocytes. | Additional information: Clone REA849 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Notch 1, TAN-1, Motch A, mT14, p300, hN1 |
| Gene, Accession # | Gene ID: 18128 |
| Catalog # | 130-112-527 |
| Price | $189 |
| Order / More Info | Notch1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gray, G. E. et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154 (3): 785-794. | Weng, A. P. et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306 (5694): 269-271. | Arruga, F. et al. (2014) Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia 28 (5): 1060-1070. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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