WIP pS488, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | WIP pS488, Human |
| Clone | REA537 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | WIP pS488 Antibody, anti-human, PE, REAfinity™. Clone REA537 recognizes the human Wiskott-Aldrich syndrome protein-interacting protein (WIP) antigen phosphorylated at serine 488 (pS488). WIP is a multifunctional adaptor implicated in a wide range of cellular functions, including cell adhesion, migration and chemotaxis, T cell activation and proliferation, and intracellular pathogen motility. WIP functions through binding to both globular and filamentous actin and several regulators of actin dynamics. WIP can also bind to and regulate the function of the actin-nucleation-promoting factor cortactin. In cells of haematopoietic origin, WIP is an important regulator of Wiskott-Aldrich syndrome protein (WASP), the expression of which is restricted to cells of this lineage. WASP is indispensable for normal leukocyte function and its importance is highlighted in the congenital disorder Wiskott-Aldrich syndrome in which missense mutations in the WAS gene result in severe immunodeficiency. Phosphorylation represents a strong candidate for regulation of WIP function, as studies have reported serine/threonine phosphorylation of WIP on a number of residues. S488 has been reported to be phosphorylated in a PKCθ-dependent manner in response to T cell receptor activation. | Additional information: Clone REA537 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | WIPF1, PRPL-2, WAS2, WASPIP, WIP |
| Gene, Accession # | Gene ID: 7456 |
| Catalog # | 130-108-866 |
| Price | $110 |
| Order / More Info | WIP pS488, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ramesh, N. et al. (1997) WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14671-14676. | Vijayakumar, V. et al. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J. Cell. Sci. 128 (2): 251-265. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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