IL-27 p28, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-27 p28, Mouse |
| Clone | REA371 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-27 p28 Antibody, anti-mouse, PE, REAfinity™. Clone REA371 recognizes the mouse IL-27 p28 antigen, a secreted molecule which binds Epstein-Barr virus-induced gene 3 (EBI3) to form the heterodimeric cytokine IL-27. IL-27 is expressed by antigen-presenting cells, including macrophages and dendritic cells, in the early phase after antigen-mediated activation. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells. In vivo, its most important role appears to be that of immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses in a range of infectious and noninfectious situations. These activities of IL-27 are dependent on simultaneous T cell receptor activation and occur in synergy with IL-12. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL-27 p28 is only poorly secreted without coexpression of EBI3. | Additional information: Clone REA371 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Il30, p28, IL-27A |
| Gene, Accession # | Gene ID: 246779 |
| Catalog # | 130-105-702 |
| Price | $46 |
| Order / More Info | IL-27 p28, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Pflanz, S. et al. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 16 (6): 779-790. | Lucas, S. et al. (2003) IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15047-15052. | Batten, M. et al. (2007) The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85 (7): 661-672. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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